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Optimizing Starting Material Quality for Cellular Therapeutics

Dominic Clarke, PhD; Marie Aragon, RN, BSN

August, 2018

This article is summarized on HemaCare's blog


Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein

Michael D Oberst, Catherine Auge, Chad Morris, Stacy Kentner, Kathy Mulgrew, Kelly McGlinchey, James Hair, Shino Hanabuchi, Qun Du, Melissa Damschroder, Hui Feng, Steven Eck, Nicholas Buss, Lolke de Haan, Andrew J Pierce, Haesun Park, Andrew Sylwester, Michael K Axthelm, Louis Picker, Nicholas P Morris, Andrew Weinberg, Scott A Hammond

May, 2018


Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells

Daniel T. MacLeod, Jeyaraj Antony, Aaron J. Martin, Rachel J. Moser, Armin Hekele, Keith J. Wetzel, Audrey E. Brown, Melissa A. Triggiano, Jo Ann Hux, Christina D. Pham, Victor V. Bartsevich, Caitlin A. Turner, Janel Lape, Samantha Kirkland, Clayton W. Beard, Jeff Smith, Matthew L. Hirsch, Michael G. Nicholson, Derek Jantz, Bruce McCreedy

April, 2018


Application of Raman Spectroscopy and Univariate Modelling As a Process Analytical Technology for Cell Therapy Bioprocessing

Application of Raman Spectroscopy and Univariate Modelling As a Process Analytical Technology for Cell Therapy Bioprocessing

March, 2018


A Positive Control for Detection of Functional CD4 T Cells in PBMC: The CPI Pool

Annemarie Schiller, Ting Zhang, Ruliang Li, Andrea Duechting, Srividya Sundararaman, Anna Przybyla, Stefanie Kuerten, Paul V. Lehmann

December, 2017


Epitope-Specific Immunotherapy Targeting CD4-Positive T Cells in Celiac Disease: Safety, Pharmacokinetics, and Effects on Intestinal Histology and Plasma Cytokines with Escalating Dose Regimens of Nexvax2 in a Randomized, Double-Blind, Placebo-Controlled Phase 1 Study

A. James M. Daveson, Hooi C. Ee, Jane M. Andrews, Timothy King, Kaela E. Goldstein, John L. Dzuris, James A. MacDougall, Leslie J. Williams, Anita Treohan, Michael P. Cooreman, Robert P. Anderson

December, 2017


Improving Gene Therapy Efficiency through the Enrichment of Human Hematopoietic Stem Cells

Katelyn E. Masiuk, Devin Brown, Jennifer Laborada, Roger P. Hollis, Fabrizia Urbinati, Donald B. Kohn

September, 2017


Progenitor Cells from Cartilage: Grade Specific Differences in Stem Cell Marker Expression

Marija Mazor, Annabelle Cesaro, Mazen Ali, Thomas M. Best, Eric Lespessaille, Hechmi Toumi

August, 2017


Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma

The Cancer Genome Atlas Research Network

August, 2017


Alpha-l-Fucosidase Immunoassay for Early Detection of Hepatocellular Carcinoma

Eric Waidely, Abdulrahman O. Al-Youbi, Abdulaziz S. Bashammakh, Mohammad S. El-Shahawi, Roger M. Leblanc

July, 2017


RUNX1 regulates site specificity of DNA demethylation by recruitment of DNA demethylation machineries in hematopoietic cells

Takahiro Suzuki, Yuri Shimizu, Erina Furuhata, Shiori Maeda, Mami Kishima, Hajime Nishimura, Saaya Enomoto, Yoshihide Hayashizaki, Harukazu Suzuki

July, 2017


Single-molecule quantification of 5-hydroxymethylcytosine for diagnosis of blood and colon cancers

Noa Gilat, Tzlil Tabachnik, Amit Shwartz, Tamar Shahal, Dmitry Torchinsky, Yael Michaeli, Gil Nifker, Shahar Zirkin, Yuval Ebenstein

July, 2017


Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response

Qiong Xue, Emily Bettini, Patrick Paczkowski, Colin Ng, Alaina Kaiser, Timothy McConnell, Olja Kodrasi, Máire F. Quigley, James Heath, Rong Fan, Sean Mackay, Mark E. Dudley, Sadik H. Kassim, and Jing Zhou

July, 2017

This article is summarized on HemaCare's blog


The important relationship between cooling and thawing rates on human t cell quality

J. Baboo, P. Kilbride, M. Delahaye, N. Gaddum, M. Blanco, J. Morris, S. Milne, S. Callens, S. Ward

May, 2017


T0001, a variant of TNFR2-Fc fusion protein, exhibits improved Fc effector functions through increased binding to membrane-bound TNFα

Yijun Shen, Gang Li, Chunying Gu, Ben Chen, Aihua Chen, Hua Li, Bei Gao, Chencai Liang, Jingsong Wu, Tong Yang, Li Jin, Yong Su

May, 2017


Slowed decay of mRNAs enhances platelet specific translation

Eric W. Mills, Rachel Green, Nicholas T. Ingolia

April, 2017


SIRT1 and AMPK pathways are essential for the proliferation and survival of primary effusion lymphoma cells

Meilan He, Brandon Tan, Karthik Vasan, Hongfeng Yuan, Fan Cheng, Suzane Ramos da Silva, Chun Lu, Shou‐Jiang Gao

April, 2017


Efficient Ex Vivo Engineering and Expansion of Highly Purified Human Hematopoietic Stem and Progenitor Cell Populations for Gene Therapy

Erika Zonari, Giacomo Desantis, Carolina Petrillo, Francesco E. Boccalatte, Maria Rosa Lidonnici, Anna Kajaste-Rudnitski, Alessandro Aiuti, Giuliana Ferrari, Luigi Naldini, Bernhard Gentner

April, 2017


Reduced representation optical methylation mapping (R2OM2)

Assaf Grunwald, Hila Sharim, Tslil Gabrieli, Yael Michaeli, Dmitry Torchinsky, Rani Arieli, Matyas Juhasz, Kathryn R Wagner, Jonathan Pevsner, Jeff Reifenberger, Alex R Hastie, Han Cao, Elmar Weinhold, Yuval Ebenstein

March, 2017


Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34+ Hematopoietic Stem and Progenitor Cells

Kai-Hsin Chang, Sarah E. Smith, Timothy Sullivan, Kai Chen, Qianhe Zhou, Jason A. West, Mei Liu, Yingchun Liu, Benjamin F. Vieira, Chao Sun, Vu P. Hong, Mingxuan Zhang, Xiao Yang, Andreas Reik, Fyodor D. Urnov, Edward J. Rebar, Michael C. Holmes, Olivier Danos, Siyuan Tan

March, 2017


Characterization of FcγRIIIA effector cells used in in vitro ADCC bioassay: Comparison of primary NK cells with engineered NK-92 and Jurkat T cells

Yao-Te Hsieh, Poonam Aggarwal, David Cirelli, Ling Gu, Teresa Surowy, Ned M. Mozier

February, 2017

This article is summarized on HemaCare's blog


Rapid, Real-time Detection of T Cell Activation Using an Agilent Seahorse XFp Analyzer

Pamela Swain, Yoonseok Kam, Kacey Caradonna, George W. Rogers, Brian P. Dranka

February, 2017


CD40-Mediated NF-κB Activation in B Cells Is Increased in Multiple Sclerosis and Modulated by Therapeutics

Ding Chen, Sara J. Ireland, Gina Remington, Enrique Alvarez, Michael K. Racke, Benjamin Greenberg, Elliot M. Frohman, Nancy L. Monson

December, 2016

This article is summarized on HemaCare's blog


Suppression of IGF binding protein-3 by palmitate promotes hepatic inflammatory responses

Hae-Ki Min, Hitoshi Maruyama, Byoung Kuk Jang, Masahiko Shimada, Faridoddin Mirshahi, Shunlin Ren, Youngman Oh, Puneet Puri, Arun J. Sanyal

December, 2016

This article is summarized on HemaCare's blog


Optimized Library Prep for Cell-Free DNA from Human Plasma

Jan Risinger, Josh Kinman, Marianna Goldrick

October, 2016

This article is summarized on HemaCare's blog


Opportunistic DNA Recombination With Epstein-Barr Virus at Sites of Control Region Rearrangements Mediating JC Virus Neurovirulence

Margaret J. Wortman, Patric S. Lundberg, Ayuna V. Dagdanova, Pranav Venkataraman, Dianne C. Daniel, Edward M. Johnson

May, 2016

This article is summarized on HemaCare's blog


Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures

Maria Cecilia Fernandes, Laura A. L. Dillon, Ashton Trey Belew, Hector Corrada Bravo, David M. Mosser, Najib M. El-Sayed

May, 2016

This article is summarized on HemaCare's blog


B cells from relapsing remitting multiple sclerosis patients support neuro-antigen-specific Th17 responses

Sara J. Ireland, Alyssa A. Guzman, Elliot M. Frohman, Nancy L. Monson

February, 2016

This article is summarized on HemaCare's blog


X-linked inhibitor of apoptosis protein mediates tumor cell resistance to antibody-dependent cellular cytotoxicity

M K Evans, S J Sauer, S Nath, T J Robinson, M A Morse, G R Devi

January, 2016


Characterization of the Cellular Output of a Point-of-Care Device and the Implications for Addressing Critical Limb Ischemia

Jennifer E. Woodell-May, Matthew L. Tan, William J. King, Matthew J. Swift, Zachary R. Welch, Michael P. Murphy, James M. McKale

November, 2015

This article is summarized on HemaCare's blog


The Effects of Platelet-rich Plasma on Cell Proliferation and Adipogenic Potential of Adipose-derived Stem Cells

Han Tsung Liao, Isaac B. James, Kacey G. Marra, J. Peter Rubin

September, 2015

This article is summarized on HemaCare's blog


A Subset of CD8αβ+ Invariant NKT Cells in a Humanized Mouse Model

Xiangshu Wen, Seil Kim, Ran Xiong, Michelle Li, Agnieszka Lawrenczyk, Xue Huang, Si-Yi Chen, Ping Rao, Gurdyal S. Besra, Paolo Dellabona, Giulia Casorati, Steven A. Porcelli, Omid Akbari, Mark A. Exley, Weiming Yuan

August, 2015


Precision Cancer Immunotherapy: Optimizing Dendritic Cell-based Strategies to Induce Tumor Antigen-specific T-cell Responses Against Individual Patient Tumors

Takuya Osada, Koji Nagaoka, Masashi Takahara, Xiao Yi Yang, Cong-Xiao Liu, Hongtao Guo, Kingshuk Roy Choudhury, Amy Hobeika, Zachary Hartman, Michael A. Morse, H. Kim Lyerly

May, 2015

This article is summarized on HemaCare's blog


Human esophageal myofibroblasts secrete pro-inflammatory cytokines in response to acid and toll-like receptor-4 ligands

Matthew Gargus, Chao Niu, John Vallone, Jana Binkley, Deborah C. Rubin, Anisa Shaker

April, 2015

This article is summarized on HemaCare's blog


STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

Juan Fu, David B. Kanne, Meredith Leong, Laura Hix Glickman, Sarah M. McWhirter, Edward Lemmens, Ken Mechette, Justin J. Leong, Peter Lauer, Weiqun Liu, Kelsey E. Sivick, Qi Zeng, Kevin C. Soares, Lei Zheng, Daniel A. Portnoy, Joshua J. Woodward, Drew M. Pardoll, Thomas W. Dubensky Jr., Young Kim

April, 2015

This article is summarized on HemaCare's blog


A Novel Technology for Multiplex Gene Expression Analysis Directly from Whole Blood Samples Stabilized at Ambient Temperature Using an RNA-Stabilizing Buffer

Chang Hee Kim, Majid Abedi, Yenbou Liu, Sree Panuganti, Francisco Flores, Kevin R. Shah, Hannah Catterall, Krishna S. Morampudi, Robert Terbrueggen

March, 2015

This article is summarized on HemaCare's blog


Nucleotide Insertions and Deletions Complement Point Mutations to Massively Expand the Diversity Created by Somatic Hypermutation of Antibodies

Peter M. Bowers, Petra Verdino, Zhengyuan Wang, Jean da Silva Correia, Mark Chhoa, Griffin Macondray, Minjee Do, Tamlyn Y. Neben, Robert A. Horlick, Robyn L. Stanfield, Ian A. Wilson, David J. King

November, 2014

This article is summarized on HemaCare's blog


The Effect of Glatiramer Acetate Therapy on Functional Properties of B Cells From Patients With Relapsing-Remitting Multiple Sclerosis

Sara J. Ireland, BA; Alyssa A. Guzman, BS; Dina E. O’Brien, BS; Samuel Hughes; Benjamin Greenberg, MD; Angela Flores, MD; Donna Graves, MD; Gina Remington, BSN, RN; Elliot M. Frohman, MD, PhD; Laurie S. Davis, PhD; Nancy L. Monson, PhD

September, 2014

This article is summarized on HemaCare's blog


Cellular Raw Material Collection in Cell Therapy: Critical Determinant of Product Quality

Scott R. Burger, MD; Louis Juliano; Wenshi Wang, PhD

June, 2014

This article is summarized on HemaCare's blog


Human-derived raw materials: Controlled, consistent collections enable successful manufacturing of cell-based regenerative medicine products

Thomas Ramos; Wenshi Wang, PhD; Jacob Okhovat; Gaytha McPherson; Scott Burger, MD

May, 2014


Identification of novel human leukocyte antigen-A*0201-restricted, cytotoxic T lymphocyte epitopes on CD133 for cancer stem cell immunotherapy

Jianfei Ji, Valeria A. Judkowski, Gentao Liu, Hongqiang Wang, Alcinette Bunying, Zhenhua Li, Minlin Xu, James Bender, Clemencia Pinilla, John S. Yu

March, 2014

This article is summarized on HemaCare's blog


Circulating Tumor Cells: Clinically Relevant Molecular Access Based on a Novel CTC Flow Cell

Jessamine P. Winer-Jones, Behrad Vahidi, Norma Arquilevich, Cong Fang, Samuel Ferguson, Darren Harkins, Cory Hill, Erich Klem, Paul C. Pagano, Chrissy Peasley, Juan Romero, Robert Shartle, Robert C. Vasko, William M. Strauss, Paul W. Dempsey

January, 2014

This article is summarized on HemaCare's blog


A Quantitative Polymerase Chain Reaction Test to Enumerate Leukocytes in Allograft Tissue and the Implications for Donor Eligibility Testing

Cari E. Podzemny, Matthew D. Brenton, Scott A. Brubaker, Russell C. Marians

December, 2013

This article is summarized on HemaCare's blog


MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells

Shufeng Liu, Chao Qiu, Ruidong Miao, Jianhua Zhou, Aram Lee, Baoming Liu, Sandra N. Lester, Weihui Fu, Lingyan Zhu, Linxia Zhang, Jianqing Xu, Daping Fan, Kui Li, Mingui Fu, Tianyi Wang

November, 2013

This article is summarized on HemaCare's blog


Turning T cells on: epigenetically enhanced expression of effector T-cell costimulatory molecules on irradiated human tumor cells

Anita Kumari, Ercan Cacan, Susanna F. Greer, Charlie Garnett-Benson

September, 2013

This article is summarized on HemaCare's blog


Evaluation of a New Recombinant Antigen-Based Virotech Treponema Pallidum Screen ELISA for Diagnosis of Syphilis

Clemens Busse, Mojdeh Heidary Navid, Andreas Strubel, Paul Schnitzler

July, 2013

This article is summarized on HemaCare's blog


Four-part leukocyte differential count based on sheathless microflow cytometer and fluorescent dye assay

Wendian Shi, Luke Guo, Harvey Kasdan, Yu-Chong Tai

January, 2013

This article is summarized on HemaCare's blog


Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody

Seung Y. Chu, PhD; Holly M. Horton, PhD; Erik Pong, MS; Irene W. L. Leung, PhD; Hsing Chen, MS; Duc-Hanh Nguyen, BS; Cristina Bautista, BS; Umesh S. Muchhal, PhD; Matthew J. Bernett, PhD; Gregory L. Moore, PhD; David E. Szymkowski, PhD; John R. Desjarlais, PhD

April, 2012

This article is summarized on HemaCare's blog


A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens

Gregory L. Moore, Cristina Bautista, Erik Pong, Duc-Hanh T. Nguyen, Jonathan Jacinto, Araz Eivazi, Umesh S. Muchhal, Sher Karki, Seung Y. Chu, Greg A. Lazar

November, 2011

This article is summarized on HemaCare's blog