CD8+ cytotoxic T cells fulfill the role dual role of regulating and/or implementing the body’s immune response by eliminating intracellular pathogens such as viruses, and some bacteria and parasites. Upon recognition of an infected cell, the CD8+ T cell initiates apoptosis through the targeted release of effector proteins contained specialized lytic granules within the T cell.
CD8+ cytotoxic T cells are isolated from leukopaks by negative selection using immunomagnetic cell separation procedures. Positive selection is also available at your request.
For cryopreserved CD8+ cytotoxic T cells, either prepare cells for long-term storage in Liquid Nitrogen vapor phase or thaw for use. Storage in liquid phase nitrogen is NOT recommended. Short-term storage of cells (less than 2 weeks) at -80°C is acceptable but should be minimized to ensure maximum stability. Once thawed, samples must be used immediately.
Testing: Donors are tested for HBV, HCV, HIV, HTLV, WNV, Trypanosoma cruzi, and Syphilis.