The SARS-CoV-2 antigen-specific T cell is an HLA-A*0201-restricted T cell line with the specificity for the KLPDDFTGCV, a peptide that corresponds to the Spike protein (position 424-433) of the novel coronavirus SARS-CoV-2.
COVID-19 antigen-specific T cells can be utilized for a multitude of applications including examining T cell proliferation, cytokine expression, and cytotoxicity in response to the immuno-modulatory activity of specific anti-COVID-19 drugs. These unique cells provide valuable insight regarding the T cell response to COVID-19 infection, thus accelerating early-stage research, drug discovery, as well as disease diagnosis and treatment.
For cryopreserved antigen-specific T cells, prepare cells for long-term storage in Liquid Nitrogen vapor phase or thaw for use. Storage in liquid phase nitrogen is NOT recommended. Short-term storage of cells (less than 2 weeks) at -80°C is acceptable but should be minimized to ensure maximum stability. Once thawed, samples must be used immediately.
Donors are tested for the blood borne pathogens HIV-1 and 2, Hepatitis B, Hepatitis C, and HTLV-1.