What Is Bone Marrow?
Human bone marrow, the semi-solid tissue found inside the spongy portions of larger bones, is the primary site of hematopoiesis – the process by which all blood and immune cells are formed. There are two portions to the bone marrow, a solid portion and a fluid portion. The fluid portion contains a large amount of hematopoietic stem cells, which can be collected via bone marrow aspiration. Hematopoietic stem cells are immature and undergo development and differentiation within the bone marrow becoming red blood cells, white blood cells, or platelets. When they mature or are near full maturity, these cells are released into circulation. Bone marrow is also a source of mesenchymal stem cells (MSC), also termed mesenchymal stromal cells, which are cultured from freshly collected adult human bone marrow. MSCs can differentiate into cartilage cells (chondrocytes), bone cells (osteoblasts), and fat cells (adipocytes).
Why Use Bone Marrow Products?
Bone marrow products are utilized across the research and development spectrum in many branches of science including oncology, blood disorders, or other immune or genetic diseases. Due to the multipotent nature of bone marrow stem cells, such as CD34+, CD133+, and MSCs, researchers can use these cellular materials to gain a better understanding of the inner workings of the human body, in drug discovery, and study cell replacement and self-repair.
How Is Bone Marrow Aspirate Collected?
The bone marrow aspiration is performed at HemaCare’s FDA-registered donor center by our qualified clinicians from IRB-consented healthy human donors. The aspirate is drawn from the posterior iliac crest (top ridge of the back of a hipbone) using a syringe attached to the needle containing anticoagulant.
Aspirate from bone marrow is shipped immediately to customers or processed on-site following collection utilizing best-in-class instruments and media and standardized protocols. Rigorous operational controls ensure customers receive reproducible and consistent high-quality cells, such as bone marrow stem cells, eliminating variability. All isolated primary cells are characterized by flow cytometry prior to cryopreservation, guaranteeing customers receive a pure and viable cell population every time.